Transconjunctival penetration of mitomycin C
نویسندگان
چکیده
منابع مشابه
Penetration of Mitomycin C in Human Bladder1
The penetration of mitomycin C (MMC) in bladder tissue was studied in patients who received intravesical chemotherapy at the time of radical cystectomy. An intravesical dose of MMC (20 mg/40 ml) was instilled and maintained in the bladder for 60 to 120 min at which time the solution was drained. Within 10 to 60 min after draining the drug solution, the bladder vasculature was ligated, and the b...
متن کاملEffect of 1-alkyl- or 1-alkenylazacycloalkanone derivatives on penetration of mitomycin C through rat skin.
(3, 7, 11-trimethyldodecyl ) azacycloheptan-2-one (7FS), l-geranylgeranylazacycloheptan-2-one (7GGU), and 1-geranylgeranylazacyclohexan-2-one (6GGU), on percutaneous penetration of mitomycin C (MMC) through rat skin in vitro were investigated in comparison with those of 1farnesylazacycloheptan-2-one (7FU) and 1-dodecylazacycloheptan-2-one (Azone) . In an in vitro diffusion experiment, 6GU, 7GS,...
متن کامل[Mitomycin C and excimer laser].
Mitomycin C is an antimetabolite agent that blocks DNA and RNA replication and protein synthesis. It has been used in several ophthalmologic areas, and recently as a modulator of corneal wound healing in excimer laser surgeries. A single application of mitomycin C during surface corneal photoablative surgery seems a safe and efficient therapeutic option for eyes with corneal opacity and/or as p...
متن کاملMitomycin-C Use in Ophthalmology
Mitomycin-C is a chemotherapeutic drug that acts by inhibiting DNA synthesis. Its use and application in ophthalmology has been increasing in recent years because of its mandatory effects on wound healing. Current applications include pterygium surgery, glaucoma surgery, corneal refractive surgery, cictracial eye disease, conjunctivalneoplasia, dacryocystorhinostomy surgeries and allergic eye d...
متن کاملEffects of BMY 25282, a mitomycin C analogue, in mitomycin C-resistant human colon cancer cells.
BMY 25282, a newly designed analogue of mitomycin C (MMC), was assessed for its non-cross-resistant cytotoxic and biochemical action against MMC-resistant human colon carcinoma cells. The analogue has an amidine substituted at position 7 of MMC and has a more efficient intracellular activation to its active species than MMC. In this study we demonstrated that BMY 25282 can overcome MMC resistan...
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ژورنال
عنوان ژورنال: Indian Journal of Ophthalmology
سال: 2008
ISSN: 0301-4738
DOI: 10.4103/0301-4738.40357